|
|
|
|
|
|
|
| |||||||
|
|
Extraocular Circadian Phototransduction in Humans
Physiological and behavioral rhythms are governed by an endogenous
circadian clock. The response of the human circadian clock to
extraocular light exposure was monitored by measurement of body
temperature and melatonin concentrations throughout the
circadian cycle before and after light pulses presented to the
popliteal region (behind the knee). A systematic relation was found
between the timing of the light pulse and the magnitude and direction of phase shifts, resulting in the generation of a phase response curve.
These findings challenge the belief that mammals are incapable of
extraretinal circadian phototransduction and have implications for the
development of more effective treatments for sleep and circadian rhythm
disorders.
*
To whom correspondence should be addressed.
This article has been cited by other articles:
- Malm, C., Lenkei, R., Sjödin, B.
(1999). Effects of eccentric exercise on the immune system in men. J. Appl. Physiol. 86: 461-468
[Abstract] [Full Text] - Blackshaw, S., Snyder, S. H.
(1999). Encephalopsin: A Novel Mammalian Extraretinal Opsin Discretely Localized in the Brain. J. Neurosci. 19: 3681-3690
[Abstract] [Full Text] - Miyamoto, Y., Sancar, A.
(1998). Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals. Proc. Natl. Acad. Sci. U. S. A. 95: 6097-6102
[Abstract] [Full Text] - Thresher, R. J., Vitaterna, M. H., Miyamoto, Y., Kazantsev, A., Hsu, D. S., Petit, C., Selby, C. P., Dawut, L., Smithies, O., Takahashi, J. S., Sancar, A.
(1998). Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses. Science 282: 1490-1494
[Abstract] [Full Text]
Volume 279, Number 5349 Issue of 16 Jan 1998,
pp. 396 - 399
©1998 by The American Association for the Advancement of Science.
|
|